Great presentation on the future of computing by the a16z folks. I particularly like slide 19 but the whole deck is well worth the read.
Basically, mobiles will be the predominant devices, interfaces and operating systems going forward so be prepared to change the assumptions we make about the entire computing landscape. Don't worry though.
Your laptop isn't going anywhere (while we still need to type) as it is still the best thing to type on but the next one you buy may just run Android or iOS and be powered by ARM chips. Goodbye Wintel?